Archives 2020
Scientific events
Consortium iPSpine in Nantes
On Jan. 29th and 30th, the consortium iPSpine (Induced pluripotent stem cell-based therapy for spinal regeneration) meeting was held in Nantes (Passage Ste Croix) and organized by RMeS team. This 5-year project falls under the European Union’s Horizon 2020 programme to fund research that improves knowledge, testing, and exploitation platforms that address the future of advanced therapies in Europe. The project is coordinated by Professor Marianna Tryfonidou at Utrecht University.
The next DEVSTEM meeting took place on Oct 6, 2020 at 10.00 am in the School of dental Surgery (Amphi Ricordeau). Presentations of Nathan PROVIN & Bastien CIMAROSTI
The DEVSTEM meeting took place on Jan 14, 2020 at 10.00 am in the School of dental Surgery (Amphi Landais). Presentations of Nathan PROVIN & Alexandre BRUNEAU
Media / Press
Sciences et Avenir - Interview of J. Guicheux
Interview of J. Guicheux in the latest publication of the journal "Sciences et Avenir" as part of an article on "Back pain - The methods that work"
J. Guicheux's talk - Rencontres du Lyos (Lyon, 15/11/2019)
Presentation of Jérôme Guicheux at : "Rencontres du LYOS" (Lyon, Nov. 15, 2019) entitled : "Biomatériaux et cellules souches pour la médecine régénératrice des articulations: la route est elle encore longue?"
V. Delplace's talk - Aviesan (Paris, 2/12/2019)
Presentation of Vianney Delplace at : "Journée Aviesan - "3D culture & organoids" (Paris, Dec. 2, 2019) entitled : "Click" hydrogels as innovative tools for 3D cell culture (and more)"
Anoucement
OVERbone
The REGOS team of the Inserm U1229-RMeS laboratory is pleased to announce the recent funding of the OVERbone proposal as an ANR collaborative research project. OVERbone will be coordinated by Valérie Geoffroy and Angélique Galvani (Inserm U1229, RMeS) and will be carried out with Pierre Weiss (Inserm U1229, RMeS) and in collaboration with Patricia Abellan and Jean Le Bideau (IMN, CNRS U6502). OVERbone aims to investigate a novel mechanism of bone formation based on extracellular vesicles (EVs) secreted by bone cells, that could be used as therapy for bone regeneration. In addition, OVERbone will demonstrate that these EVs are altered during aging either in quantity or in quality and that this alteration contributes to bone aging.
Launching of the second transversal Inserm program dedicated to Aging (AGEMED 2.0)
The STEP Team is happy to announce that the second transversal Inserm program dedicated to Aging (AGEMED 2.0) will receive a 1.5 M€ grant for the next three years. This research program, coordinated by Eric Gilson (Nice), gathers 11 Research teams from Paris, 2 from Marseille and Grenoble and 1 from Montpellier and Nantes (RMeS STEP team, J.Guicheux and C. Vinatier). The long-term vision of this Inserm program on aging is to ameliorate age-related disorders, improving overall healthspan and reducing public health costs. AGEMED 2.0 will be organized around two main axis. The first axis aims at deciphering the cell senescence code to improve healthspan in chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and osteoarthritis. The second axis deals with integrated approaches to prevent and treat neuroaging disorders in various pre-clinical models. RMeS will receive a financial support for three years to test the efficacy of senolytic compounds in several murine models of osteoarthritis.
Launching of the INSERM French network : NetwOArk
RMES is happy to announce the launching of the INSERM French network dedicated to peripheral and spine osteoarthritis : NetwOArk. Jerome Guicheux will serve NetwOArk as national coordinator with Francis Berenbaum as a co-coordinator. NetwOArk aims bringing together all the scientific actors involved in osteoarthritis research in order to federate and promote the emergence of high-level scientific works in this field. NetwOArk is created for 4 years and is supported by INSERM, Aviesan and ITMO PMN. NetwOArk is organized around 4 work packages coordinated by Claire Vinatier and Esther Potier (WP 1 pathophysiology), Khorng Ea and Yves-Marie Pers (WP2 disease bio markers), Christelle N’Guyen and Jeremy Sellam (WP3 prevention and treatment) and David Moulin and Emeline Perrier-Groult (WP4 innovation). A first scientific event will be organized in 2020 to gather the French actors involved in Osteoarthritis research. We hope to meet you all to share recent advances in basic, translational and clinical research dedicated to this incurable and disabling disease.
New funding of BIOREGATE
The STEP team (UMR 1229 INSERM-Nantes University-ONIRIS) is pleased to announce that the project DISCODOG was awarded of BIOREGATE (Région Pays de la Loire) grant (veterinary clinic grant). The project is led by Johann CLOUET and Marion FUSELLIER. This project will be performed in collaboration with the MINT laboratory (INSERM 1066 CNRS 6021) in Angers (Elise LEPELTIER).The two objectives of DISCODOG are to develop a new therapeutic tool to treat discogenic lumbalgia, consisting in miRNA encapsulated in lipid nanocapsules and to validate a new method to detect early signs of disc degeneration in canine patients. After intradiscal injection in clinic dogs, security and efficacy of the treatment will be followed by the mean of orthopedic and neurologic examination as well as by MRI, during 6 months. 120 k€ will be dedicated to the DISCODOG project during 2 years. The project will begin during the first semester of 2020..
People events
Rémy Cochereau
Semi-permeable vesicles produced by microfluidics to tune the phase behaviour of encapsulated macromolecules
INRAE Nnantes
December 7, 2020, 10h00 - Via Zoom
Sébastien Grastilleur
Sébastien is post-doctoral researcher. He will work on ANR INDEED
He joined our unit on November 1st 2020
His supervisor is Catherine Le Visage
Baptiste Charbonnier
Baptiste is post-doctoral researcher. He will work on ANR GIJAW
He joined our unit on November 1st 2020
His supervisors are Pierre Corre & Pierre Weiss
Laura Bachir
Laura is a M2 student. She will work on LFC project which aims to develop a new injectable biomaterial
Se joined our unit on October 12th 2020
Her supervisors are Hélène Gautier, Aurélie Billon & Valérie Geoffroy
Congratulations to Giulia Frangi for her PhD Defense !
Giulia defended her thesis on December 15th, 2020 at 2.00 pm
Study of the role of PiT2 at the interface between bone and adipose tissues
Directeur de thèse: S. Beck - Co-directeur : L. Beck
Congratulations to Audrey Smith for her PhD Defense !
Audrey defended her thesis on November 10th, 2020 at 2.00 pm
Cellules stromales mésenchymateuses encapsulées dans des microparticules d'alginate : conception et évaluation de leur potentiel anti-arthrosique après injection intra-articulaire chez le lapin
Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux
Congratulations to Cyril d'Arros for his PhD Defense !
Cyril defended his thesis on October 2nd, 2020
Développement d'un substitut osseux hautement malléable et cohésif, un nouveau concept de matrice pour la régénération osseuse
Directeur de thèse: O. Malard - Co-directeur : G. Daculsi
Florian Segeron
Florian is a M2 student. He will work on the formulation of a hyalurronic acid hydrogel
He will join our unit on October 12th 2020
His supervisors are Alexis Gaudin & Hélène Gautier
Yoan Moreau
Yoan is an INSERM Technician. He works on SC3M Platform
He joined our unit on October 1st 2020
Mathilde Ambrosino
Mathilde Ambrosino is a PhD student. She works on intra-articular injection of mesenchymal stem cells associated with a cytoprotective boronic hydrogel: assessment in a rabbit model of osteoarthritis.
She joined our unit on October 1st 2020
Her supervisor is Catherine Le Visage
Congratulations to Sarah Beck for her HDR !
Sarah defended her HDR on September 30, 2020 at 2.00 pm (Amphi Ricordeau)
Emilie Hascoët
Emilie Hascoët is a PhD student and hospitalo-university assistant. She will work on characterization of inflammatory osteoclast precursors in periodontitis
She joined our unit on September 1st 2020
Her supervisor is Alexandra Cloitre
Claire De Fourmestraux
Claire De Fourmestraux is a PhD student and an hospital practitioner in equine surgery. She will work on the interest of resorbable composite biomaterials in osteochondral regeneration.
She joined our unit on September 1st 2020
Her supervisors are Olivier Gauthier & Gwénola Touzot-Jourde
Marie Guicheteau
Marie is a M2 student. She will work on understanding of the multifunctionality of PiT proteins
She joined our unit on September 14th 2020
Her supervisor is Sarah Beck
Estelle Bray
Estelle is a M2 student. She will work on the development of an adhesive hydrogel loaded with nano particles of calcium phosphates with anti-bacterial aim
She will join our unit on October 5th 2020
Her supervisors are Pierre Weiss & Gildas Rethoré
Floriane Kellner
Floriane is a PhD student. She will work on ANR IXBONE project.
She joined our unit on September 1st 2020
Her supervisors are Angélique Galvani & Valérie Geoffroy
PhD Defense of Pierre Tournier
Congratulations to Pierre who defended his thesis on December 18, 2019 !
Caractérisation biologique d'une pâte osseuse allogénique pour la médecine régénératrice du squelette
Directeur de thèse: P. Weiss - Co-directeur : J. Guicheux - Co-encadrant : A. Gaudin
Prof. Fan Yang
From Zip lining to Lego building: Novel Hydrogels for Stem Cell-based Tissue Regeneration and Disease Modeling
University of Stanford
Jan 17, 2020, 14h30 - Amphi Landais (Dental Faculty)
Charlotte Fosse
Charlotte is in engineering school. She will work on image and data analysis for mapping of intracranial aneurysms
She joined our unit on May 20th 2020
Her supervisor is Florent Autrusseau
Floriane Etienne
Floriane is clinical research assistant. She will work on Discodog and IPSPine projects
She joined our unit on March 2nd 2020
Her supervisors are Marion Fusellier & Johann Clouet
Fatima Fneich
Fatima is post-doctoral researcher. She will work on 3D printing
She joined our unit on March 2nd 2020
Her supervisor is Pierre Weiss
PhD Defense of Leslie Frapin
Congratulations to Leslie who defended her thesis on December 11, 2019 !
Ingénierie tissulaire du disque intervertébral: Développement d'un système à libération séquentielle de facteurs biologiques pour la réparation endogène du disque intervertébral humain
Directeur de thèse: C. Le Visage - Co-directeur : J. Guicheux - Co-encadrant : J. Clouet
Pauline Le Cam
Pauline is a professional license student. She will work on histological analysis of biomaterials for bone regeneration
She joined our unit on March 2nd 2020
Her supervisors are Hilel Moussi and Julie Le Soeur
Meggane Amiot
Meggane is a M2 student. She will work on characterisation of extracellular vesicles of bone origin
She joined our unit on March 2nd 2020
Her supervisors are Valérie Geoffroy and Angélique Galvani
Mathilde Ambrosino
Mathilde is a M2 student. She will work on stromal mesenchymal cell encapsulation in hydrogels for a potential application in arthrosis
She joined our unit on Feb. 3th 2020
Her supervisors are Catherine Le Visage and Fabien Nativel
Charles Hervochon
Charles is a Pharma student. He will work on mesenchymal stem cell encapsulation
He joined our unit on Feb. 3th 2020
His supervisors are Hélène Gautier and Pierre Weiss
Davy Aubeux
Davy is a PhD student. He will work on resolution of inflammation in clinical situations associated with very common conditions such as dental pulp
He joined our unit on Feb. 3th 2020
His supervisors are Valérie Geoffroy & Alexis Gaudin
Carine Behloul
Carine is a Pharma student. She will work on the development of a composite cement formulation for bone regeneration
She joined our unit on Feb. 3th 2020
Her supervisors are Pierre Weiss and Marie-Michèle Germaini
Charlotte Plard
Charlotte is a M2 student. She will work on mesenchymal stem cells for the treatment of osteoarthritis
She joined our unit on Jan. 13th 2020
Her supervisor is Claire Vinatier
Feras Oyoun
Feras is a M2 student. He will work on REGOMIR Project
He joined our unit on Jan. 6th 2020
His supervisors are Elise Lepeltier (MINT Angers), Angélique Galvani & Valérie Geoffroy
Nathaly Gavira
Nathaly is a M2 student. She will work on comparative anatomy of IVD
She joined our unit on Jan. 2nd 2020
Her supervisors are Johann Clouet, Marion Fusellier & Cyril Decante
Dr. Arnaud Scherberich
Adipose-derived cells for bone regeneration: Generation of bone germs, developmental engineering and use of nanoparticles
University of Bâle
Jan 8, 2020, 11h00 - Amphi Landais (Dental Faculty)
Clément Morin
Maxime Métayer